9/23/2025

Alteplase Injection

Reason for the Shortage

- Genentech has Activase 50 mg and 100 mg kits available.

Available Products

- Activase intravenous lyophilized powder for injection, Genentech, 100 mg, kit, 1 count, NDC 50242-0065-27
- Activase intravenous lyophilized powder for injection, Genentech, 50 mg, kit, 1 count, NDC 50242-0044-13

Alternative Agents & Management

- Genentech has issued a Dear Healthcare Provider letter which provides instructions on how to prepare a dose over 50 mg using Activase 50 mg vials. The Dear Healthcare Provider letter can be found at https://www.gene.com/download/pdf/Activase_DHCP_Important-Prescribing-Information_11-14-24.pdf. The full instructions for alternate dose preparation can be found at :https://www.gene.com/download/pdf/activase_instructions_for_alternate_preparation.pdf.

Updated

Updated September 23, 2025 by Leslie Jensen, PharmD, Drug Information Specialist. Created November 22, 2024 by Leslie Jensen, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

Drug Shortage Bulletins are copyrighted by the Drug Information Service of the University of Utah and provided by ASHP as its exclusive authorized distributor. ASHP and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this Bulletin. Neither ASHP nor the University of Utah endorses or recommends the use of any particular drug. Any application of this information for any purpose shall be limited to personal, non-commercial use.

« Back to Drug Shortage Product Bulletins

Subscribe to AHFS Clinical Drug Information to get direct access to integrated drug shortages content, plus comprehensive and actionable drug information.