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8/25/2025

Methylprednisolone Acetate Injection

Products Affected - Description

    • Depo-Medrol injection, Pfizer, 40 mg/mL, 1 mL single dose vial, 25 count, NDC 00009-3073-03
    • Depo-Medrol injection, Pfizer, 40 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00009-0280-02
    • Depo-Medrol injection, Pfizer, 40 mg/mL, 5 mL multiple dose vial, 25 count, NDC 00009-0280-51
    • Depo-Medrol injection, Pfizer, 80 mg/mL, 1 mL single dose vial, 25 count, NDC 00009-3475-03
    • Depo-Medrol injection, Pfizer, 80 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00009-0306-02
    • Depo-Medrol injection, Pfizer, 80 mg/mL, 5 mL multiple dose vial, 25 count, NDC 00009-0306-12
    • Methylprednisolone Acetate injection, Eugia US, 40 mg/mL, 10 mL multiple dose vial, 1 count, NDC 55150-0313-01
    • Methylprednisolone Acetate injection, Sandoz, 40 mg/mL, 10 mL vial, 1 count, NDC 00781-3522-70
    • Methylprednisolone Acetate injection, Sandoz, 40 mg/mL, 5 mL vial, 1 count, NDC 00781-3522-75
    • Methylprednisolone Acetate injection, Sandoz, 80 mg/mL, 5 mL vial, 1 count, NDC 00781-3516-75

Reason for the Shortage

    • Amneal has methylprednisolone acetate injection available.
    • Eugia did not provide a reason for the shortage.
    • Pfizer has methylprednisolone acetate injection on shortage due to manufacturing delays and increased demand.
    • Sagent has methylprednisolone acetate injection available.
    • Sandoz did not provide a reason for the shortage.
    • Teva discontinued methylprednisolone acetate injection in July 2023.

Available Products

    • Depo-Medrol injection, Pfizer, 20 mg/mL, 5 mL multiple dose vial, 1 count, NDC 00009-0274-01
    • Depo-Medrol injection, Pfizer, 40 mg/mL, 1 mL single dose vial, 1 count, NDC 00009-3073-01
    • Depo-Medrol injection, Pfizer, 40 mg/mL, 10 mL multiple dose vial, 1 count, NDC 00009-0280-03
    • Depo-Medrol injection, Pfizer, 40 mg/mL, 10 mL multiple dose vial, 25 count, NDC 00009-0280-52
    • Depo-Medrol injection, Pfizer, 80 mg/mL, 1 mL single dose vial, 1 count, NDC 00009-3475-01
    • Methylprednisolone Acetate injection, Amneal, 40 mg/mL, 1 mL single dose vial, 1 count, NDC 70121-1573-01
    • Methylprednisolone Acetate injection, Amneal, 40 mg/mL, 1 mL single dose vial, 25 count, NDC 70121-1573-05
    • Methylprednisolone Acetate injection, Amneal, 80 mg/mL, 1 mL single dose vial, 1 count, NDC 70121-1574-01
    • Methylprednisolone Acetate injection, Amneal, 80 mg/mL, 1 mL single dose vial, 25 count, NDC 70121-1574-05
    • Methylprednisolone Acetate injection, Amneal, 80 mg/mL, 5 mL single dose vial, 1 count, NDC 70121-1610-01
    • Methylprednisolone Acetate injection, Amneal, 80 mg/mL, 5 mL single dose vial, 25 count, NDC 70121-1610-05
    • Methylprednisolone Acetate injection, Sagent, 40 mg/mL, 10 mL multiple dose vial, 1 count, NDC 25021-0820-10
    • Methylprednisolone Acetate injection, Sagent, 40 mg/mL, 5 mL multiple dose vial, 1 count, NDC 25021-0820-05
    • Methylprednisolone Acetate injection, Sagent, 80 mg/mL, 5 mL multiple dose vial, 1 count, NDC 25021-0821-05

Estimated Resupply Dates

    • Eugia has methylprednisolone acetate 40 mg/mL 10 mL vials on back order and the company cannot estimate a release date.
    • Sandoz has methylprednisolone acetate 40 mg/mL 5 mL and 10 mL vials and 80 mg/mL 5 mL vials on back order and the company cannot estimate a release date.
    • Pfizer has Depo-Medrol 40 mg/mL 1 mL vials in 25 count and 40 mg/mL 5 mL vials in 25 count on back order and the company estimates a release date of September 2025. The 80 mg/mL 1 mL vials in 25 count are on back order and the company estimates a release date of November 2025. The 80 mg/mL 5 mL vials in 1 count and 25 count are on back order and the company estimates a release date of October 2025. The 40 mg/mL 1 mL vials in 1 count are available in limited supply.

Updated

Created August 25, 2025 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

Drug Shortage Bulletins are copyrighted by the Drug Information Service of the University of Utah and provided by ASHP as its exclusive authorized distributor. ASHP and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this Bulletin. Neither ASHP nor the University of Utah endorses or recommends the use of any particular drug. Any application of this information for any purpose shall be limited to personal, non-commercial use.

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