7/6/2026

Levofloxacin Oral Solution

Products Affected - Description

- Levofloxacin oral solution, Lannett, 25 mg/mL, 100 mL bottle, NDC 00527-1948-66
- Levofloxacin oral solution, Lannett, 25 mg/mL, 200 mL bottle, NDC 00527-1948-68
- Levofloxacin oral solution, Lannett, 25 mg/mL, 480 mL bottle, NDC 00527-1948-70

Reason for the Shortage

- Lannett did not provide a reason for the shortage.
- Levofloxacin oral tablets are not affected by this shortage.

Available Products

- There are no presentations available

Estimated Resupply Dates

- Lannett has levofloxacin oral solution on back order and the company cannot estimate a release date.

Implications for Patient Care

- Levofloxacin is a third-generation fluoroquinolone antibiotic used for the treatment of susceptible infections[1]
- Levofloxacin is the only available third-generation fluoroquinolone[1]

Alternative Agents & Management

Table 1. Fluoroquinolones Available in Oral Presentations
Drug Name	Generation	Gram Negative Coverage	Gram Positive Coverage	Anaerobic Coverage	Atypical Coverage
Ciprofloxacin2	Second	+++	+	-	+
Ofloxacin3	Second	+++	+	-	-
Levofloxacin1	Third	+++	++	-	+
Moxifloxacin4	Fourth	+++	++	+	+
Delafloxacin5	Fourth	+++	+++	+	+

References

1. Levofloxacin tablet [prescribing information]. Piscataway, NJ: Camber Pharmaceuticals, Inc; July 2024.
2. Cipro tablet (ciprofloxacin) [prescribing information]. Whippany, NJ: Bayer HealthCare Pharmaceuticals, Inc; September 2024.
3. Ofloxacin tablet [prescribing information]. Sacramento, CA: Nivagen Pharmaceuticals; December 2018.
4. Moxifloxacin tablets [prescribing information]. East Windsor, NJ: Aurobindo Pharma USA, Inc; September 2025.
5. Baxdela tablet (delafloxacin) [prescribing information]. Lincolnshire, IL: Melinta Therapeutics, LLC; June 2021.

Updated

Updated July 6, 2026 by Rachael Freeman, PharmD, BCPS. Created September 15, 2023 by Leslie Jensen, PharmD, Drug Information Specialist. © 2026, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

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