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2/19/2026

Estradiol Transdermal System

Products Affected - Description

    • Estradiol transdermal patch, Sandoz, 0.025 mg/24 hour, 4 count, NDC 00781-7119-54
    • Estradiol transdermal patch, Sandoz, 0.0375 mg/24 hour, 4 count, NDC 00781-7122-54
    • Estradiol transdermal patch, Sandoz, 0.05 mg/24 hour, 4 count, NDC 00781-7133-54
    • Estradiol transdermal patch, Sandoz, 0.06 mg/24 hour, 4 count, NDC 00781-7134-54
    • Estradiol transdermal patch, Sandoz, 0.075 mg/24 hour, 4 count, NDC 00781-7136-54
    • Estradiol transdermal patch, Sandoz, 0.1 mg/24 hour, 4 count, NDC 00781-7104-54
    • Dotti transdermal patch, Amneal, 0.025 mg/24 hour, 8 count, NDC 65162-0989-08
    • Dotti transdermal patch, Amneal, 0.0375 mg/24 hour, 8 count, NDC 65162-0992-08
    • Lyllana transdermal patch, Amneal, 0.0375 mg/24 hour, 8 count, NDC 65162-0148-08
    • Lyllana transdermal patch, Amneal, 0.1 mg/24 hour, 8 count, NDC 65162-0228-08

Reason for the Shortage

    • Amneal did not provide a reason for the shortage.
    • Viatris has estradiol transdermal patches available.
    • Noven has estradiol transdermal patches available. Product is distributed by Grove Pharmaceuticals.
    • Sandoz did not provide a reason for the shortage.
    • Zydus has estradiol transdermal patches available.

Available Products

    • Estradiol transdermal patch, Mylan (Viatris), 0.025 mg/24 hour, 4 count, NDC 00378-3349-99
    • Estradiol transdermal patch, Mylan (Viatris), 0.0375 mg/24 hour, 4 count, NDC 00378-3360-99
    • Estradiol transdermal patch, Mylan (Viatris), 0.05 mg/24 hour, 4 count, NDC 00378-3350-99
    • Estradiol transdermal patch, Mylan (Viatris), 0.06 mg/24 hour, 4 count, NDC 00378-3361-99
    • Estradiol transdermal patch, Mylan (Viatris), 0.075 mg/24 hour, 4 count, NDC 00378-3351-99
    • Estradiol transdermal patch, Mylan (Viatris), 0.1 mg/24 hour, 4 count, NDC 00378-3352-99
    • Dotti transdermal patch, Amneal, 0.05 mg/24 hour, 8 count, NDC 65162-0993-08
    • Dotti transdermal patch, Amneal, 0.075 mg/24 hour, 8 count, NDC 65162-0995-08
    • Dotti transdermal patch, Amneal, 0.1 mg/24 hour, 8 count, NDC 65162-0997-08
    • Lyllana transdermal patch, Amneal, 0.025 mg/24 hour, 8 count, NDC 65162-0126-08
    • Lyllana transdermal patch, Amneal, 0.05 mg/24 hour, 8 count, NDC 65162-0149-08
    • Lyllana transdermal patch, Amneal, 0.075 mg/24 hour, 8 count, NDC 65162-0150-08
    • Estradiol transdermal patch, Mylan (Viatris), 0.025 mg/24 hour, 8 count, NDC 00378-4619-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.025 mg/24 hour, 8 count, NDC 00378-4644-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.0375 mg/24 hour, 8 count, NDC 00378-4643-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.0375 mg/24 hour, 8 count, NDC 00378-4620-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.05 mg/24 hour, 8 count, NDC 00378-4642-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.05 mg/24 hour, 8 count, NDC 00378-4621-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.075 mg/24 hour, 8 count, NDC 00378-4641-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.075 mg/24 hour, 8 count, NDC 00378-4622-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.1 mg/24 hour, 8 count, NDC 00378-4640-26
    • Estradiol transdermal patch, Mylan (Viatris), 0.1 mg/24 hour, 8 count, NDC 00378-4623-26
    • Estradiol transdermal patch, Noven, 0.025 mg/24 hour, 8 count, NDC 68968-3425-08
    • Estradiol transdermal patch, Noven, 0.0375 mg/24 hour, 8 count, NDC 68968-3437-08
    • Estradiol transdermal patch, Noven, 0.05 mg/24 hour, 8 count, NDC 68968-3450-08
    • Estradiol transdermal patch, Noven, 0.075 mg/24 hour, 8 count, NDC 68968-3475-08
    • Estradiol transdermal patch, Noven, 0.1 mg/24 hour, 8 count, NDC 68968-3410-08
    • Estradiol transdermal patch, Zydus, 0.05 mg/24 hour, 8 count, NDC 70710-1193-08
    • Estradiol transdermal patch, Zydus, 0.075 mg/24 hour, 8 count, NDC 70710-1194-08
    • Estradiol transdermal patch, Zydus, 0.1 mg/24 hour, 8 count, NDC 70710-1195-08

Estimated Resupply Dates

    • Amneal has Lyllana 0.0375 mg/24 hour patches and 0.1 mg/ 24 hour patches in 8 count packages on back order and the company cannot estimate a release date.
    • Amneal had Dotti 0.025 mg/24 hour and 0.0375 mg/24 hour patches in 8 count packages on back order and the company cannot estimate a release date.
    • Sandoz has estradiol 0.05 mg/24 hour transdermal patch in 4 count packages and 0.06 mg/24 hour transdermal patch in 4 count packages on back order and the company estimates a release date of late-February 2026. All other presentations are available and being allocated.

Updated

Updated February 19, 2026 by Michelle Wheeler, PharmD, Drug Information Specialist. Created January 30, 2026 by Leslie Jensen, PharmD, Drug Information Specialist. © 2026, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

Drug Shortage Bulletins are copyrighted by the Drug Information Service of the University of Utah and provided by ASHP as its exclusive authorized distributor. ASHP and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this Bulletin. Neither ASHP nor the University of Utah endorses or recommends the use of any particular drug. Any application of this information for any purpose shall be limited to personal, non-commercial use.

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