Drug Shortages Statistics

National Drug Shortages:
January 2001 to December 2025

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SUMMARY

• The number of active drug shortages is 216, up slightly from last quarter’s 214, but significantly lower than the all-time high of 323 in the first quarter of 2024.
• The number of new shortages identified during 2025 is 89, the lowest number since 2006.
• Fifteen percent of active drug shortages are controlled substances. Patients with chronic pain or ADHD may struggle to fill monthly prescriptions. Health systems may struggle to obtain sufficient supplies needed for surgeries and procedures.
• The current influenza season has resulted in increased demand for oseltamivir, which may affect availability at pharmacies.
• Long-standing shortages are beginning to resolve. Three-quarters of all active shortages (75%) started in 2022 or later.
• Lower numbers of shortages do not necessarily translate into fewer patients impacted, as a single shortage can impact large numbers of patients.
• The workload required to manage shortages, including work to change pharmacy automation and electronic health records, adds to the challenges of pharmacy staff shortages.

Selected Links of Interest

• National Academies of Science, Engineering, and Medicine: Improving Resiliency in the US Pharmaceutical Supply Chain Through Make-Buy-Invest Strategic Actions: A Workshop
• Brookings: China’s role in US Drug Supply Chains
• Government Accountability Office: Report on Drug Shortages (April 2025)
• Brookings: Federal Policies to Address Persistent Generic Drug Shortages
• ASHP: Drug Shortage Survey Report - Fluids
• ASHP Policy Solutions to Address the Drug Shortage Crisis
• Energy & Commerce Health Subcommittee (hearing)
• Senate Committee on Homeland Security & Governmental Affairs (hearing and report)
• Health Affairs: Building Resilience Into US Prescription Drug Supply Chains
• ASHP: Improving the Quality and Resilience of the United States Healthcare Supply Chain

For More Information

All data provided by the University of Utah Drug Information Service. ASHP and the University of Utah maintain a drug shortage database that tracks drug availability across the nation.

For more information, visit ashp.org/drug-shortages or contact:

Erin R. Fox, PharmD, MHA, BCPS
Associate Chief Pharmacy Officer - Shared Services
University of Utah Drug Information Service
linkedin.com/in/erin-r-fox-utah
@foxerinr.bsky.social

Michael Ganio, PharmD, BCPS, FASHP
Senior Director, Pharmacy Practice and Quality
ASHP
linkedin.com/in/michaelganio

Please contact Dr. Fox for permission to reprint data.