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Navigating the Complex Landscape of Pulmonary Arterial Hypertension: A Roadmap for Pharmacists

The last 30 years have seen significant advances in the diagnosis, treatment, and management of pulmonary arterial hypertension (PAH). Improvements in understanding the pathways underlying endothelial dysfunction and vascular arteriole remodeling involved in the pathogenesis of PAH, targeted therapies, and enhanced diagnostic and monitoring tools are reflected in new evidence-based guidelines. This educational activity will present the latest guidelines and recommended treatment options for PAH, including drug selection, combination therapies, and when and how to adjust and escalate treatment. This activity will also discuss drug therapy mechanisms of action, potential interactions, adverse effects, and considerations to support access and adherence.

Tuesday, Dec. 9
11:30 a.m. - 1 p.m. PT (2:30 - 4 p.m. ET)

Symposium Location: Islander Ballroom G, Lower Level, Mandalay Bay North Convention Center

Come early! Seating is limited and provided on a first-come, first-served basis.

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Registration is required for the webinar.

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Speakers

Jared Frost, PharmD, BCCP, Activity Chair
Clinical Pharmacy Specialist– Cardiology
Cardiology Pharmacy Residency Director
Advocate Health – Aurora St. Luke's Medical Center
Milwaukee, Wisconsin

Jared Frost is a Clinical Pharmacy Specialist in cardiology and the PGY2 Cardiology Residency Program Director at Aurora St. Luke's Medical Center in Milwaukee, WI. Dr. Frost earned his Doctor of Pharmacy degree from Drake University and completed both PGY1 and PGY2 Cardiology Pharmacy Residencies at Aurora St. Luke's. In his current role he oversees medication practices across the cardiac catheterization and electrophysiology labs, cardiovascular surgery, and pulmonary hypertension services. Dr. Frost is an active member of the American College of Cardiology, the National Lipid Association, and the Pharmacy Society of Wisconsin.

Zachary Klick, PharmD, BCCP, BCPS, BCACP, CPP
Cardiology Pharmacist
Cardiology Pharmacy Residency Program Director
Atrium Health Wake Forest Baptist
Winston Salem, North Carolina

Zachary Klick is a board-certified clinical pharmacist specializing in cardiology. He earned his PharmD from Duquesne University and completed his PGY1 at Carilion Clinic Roanoke Memorial Hospital, followed by a PGY2 in Cardiology at HCA/UTHSC. Dr. Klick has experience in both inpatient and outpatient cardiology, managing patients with advanced heart failure, pulmonary hypertension, and coronary artery disease.

Target Audience

This activity was planned to meet the educational needs of pharmacists who practice in hospitals, health systems, ambulatory clinics, and community settings who care for or are interested in the care of patients with pulmonary arterial hypertension.

Learning Objectives

Summarize the pathophysiology and disease progression of PAH, with a focus on pathways that are therapeutic targets for treatment.
Apply guideline-directed risk stratification for PAH to select treatment options and distinguish risk status as an indicator of disease progression.
Analyze the rationale and evidence for combining therapies to simultaneously target multiple pathways.
Identify how to initiate, adjust and escalate combination therapy to reach treatment goals using the latest evidence and guidelines.
Apply the mechanisms of action, clinical efficacy, safety, dosing, administration, and real-world experience of therapies to treat PAH.

Agenda

11:30 a.m. – Welcome and Introductions
Jared Frost
11:35 a.m. – Trials Pathophysiology and diagnosis of pulmonary arterial hypertension (PAH)
Zachary Klick
11:50 a.m. – Guidelines and Evidence-based Treatment of PAH
Jared Frost
12:20 p.m. – Therapy Considerations for PAH
All Faculty
12:50 p.m. – Faculty Discussion, Questions and Answers
All Faculty

Accredited for CPE

ACPE #: 0204-0000-25-409-L01-P
CE Credit: 1.5 contact hours (0.15 CEUs)
Activity Type: Application-based
Activity Fee: No charge

To Claim CE for the webinar, enter the CE code announced during the activity and complete the evaluation.