AHFS Drug Reassignments
The following describes drug assignments and changes to the AHFS Pharmacologic-Therapeutic Classification©. This is only a partial listing of the AHFS classification system. The full classification, along with a list of drugs covered in AHFS DI and their corresponding classes, is available in the print edition of AHFS and electronically as a dataset that can be licensed. Reproduction, storage on a retrieval system, or transmission of this material or any part thereof in any form or by any means without the express written permission of the American Society of Health-System Pharmacists is prohibited.
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AHFS Drug Reassignments
| Drug Name | Active Ingredients | Change Date | Old AHFS Class | New AHFS Class |
|---|---|---|---|---|
| Gralise; Horizant; Neurontin | Gabapentin | 09/03/2026 | 28:12.28 - GABA-mediated Anticonvulsants; 28:08.92 - Analgesics and Antipyretics, Miscellaneous | 28:12.10 - Gabepentinoids; 28:08.92 - Analgesics and Antipyretics, Miscellaneous |
| Lyrica | Pregabalin | 09/03/2026 | 28:12.28 - GABA-mediated Anticonvulsants; 28:40 - Fibromyalgia Agents | 28:12.10 - Gabepentinoids; 28:40 - Fibromyalgia Agents |
| Amtagvi | lifileucel | 07/27/2026 | 26:04 - Cellular Therapy | 26:04 - Cellular Therapy; 10:00 - Antineoplastic Agents |
| Cardizem | dilTIAZem | 06/24/2026 | 24:04.04.24 - Class IV Antiarrhythmics | 24:04.04.24 - Class IV Antiarrhythmics; 24:28 - Calcium-Channel Blocking Agents |
| Calan; Covera-HS; Isoptin SR; Tarka; Verelan; Verelan PM | Verapamil | 06/24/2026 | 24:04.04.24 - Class IV Antiarrhythmics | 24:04.04.24 - Class IV Antiarrhythmics; 24:28 - Calcium-Channel Blocking Agents |
| Cardamyst | etripamil | 06/24/2026 | 24:04.04.24 - Class IV Antiarrhythmics | 24:04.04.24 - Class IV Antiarrhythmics; 24:28 - Calcium-Channel Blocking Agents |
| Pylarify® | Piflufolastat F 18 | 03/11/2026 | 78:00 - Radioactive Agents | 36:92 - Diagnostic Agents, Miscellaneous |
| Vykat XR | diazoxide choline | 02/02/2026 | 28:20.92 - Anorexigenic Agents and Stimulants, Miscellaneous | 28:20.08.92 - Anorexigenic Agents, Miscellaneous |
| Vanrafia | atrasentan | 06/23/2025 | 48:48.12 - Endothelin receptor antagonists | 92:48 - IgA nephropathy |
| Filspari® | sparsentan | 06/23/2025 | 48:48.12 - Endothelin receptor antagonists; 24:32.92 - Renin-Angiotensin-Aldosterone System Inhibitors, Miscellaneous | 92:48 - IgA nephropathy; 24:32.92 - Renin-Angiotensin-Aldosterone System Inhibitors, Miscellaneous |
| Tryngolza | olezarsen | 06/23/2025 | 24:06.92 - Antilipemic Agents, Miscellaneous | 24:06.92 - Antilipemic Agents, Miscellaneous; 92:18 - Antisense Oligonucleotides |
| Lutathera® | lutetium Lu-177 dotatate | 04/07/2025 | 10:00 - Antineoplastic Agents | 10:00 - Antineoplastic Agents; 78:00 - Radioactive Agents |
| Syfovre | Pegcetacoplan (Geographic Atrophy) | 04/02/2025 | 52:92 - EENT Drugs, Miscellaneous | 52:44 - Macular Degeneration Agents; 90:20 - Complement Inhibitor Agents |
| Izervay | Avacincaptad Pegol | 04/02/2025 | 52:92 - EENT Drugs, Miscellaneous | 52:44 - Macular Degeneration Agents; 90:20 - Complement Inhibitor Agents |
| Aggrenox; Persantine | Dipyridamole | 02/06/2025 | 36:18 - Cardiac Function | 20:12.18 - Platelet-aggregation Inhibitors; 36:18 - Cardiac Function |
| N/A | Benzodiazepines General Statement | 11/26/2024 | 28:24.08 - Benzodiazepines; 28:12.08 - Benzodiazepines | 28:24.08 - Benzodiazepines; 28:12.08 - Benzodiazepines |