
AHFS Class Changes
The following describes drug assignments and changes to the AHFS Pharmacologic-Therapeutic Classification©. This is only a partial listing of the AHFS classification system. The full classification, along with a list of drugs covered in AHFS DI and their corresponding classes, is available in the print edition of AHFS and electronically as a dataset that can be licensed. Reproduction, storage on a retrieval system, or transmission of this material or any part thereof in any form or by any means without the express written permission of the American Society of Health-System Pharmacists is prohibited.
Please contact us at ahfs@ashp.org if you have any questions.
AHFS Class Changes
AHFS Class | Change Description | Change Date |
---|---|---|
8:12.28.36 - Triazaacenaphthylenes | New subclass | 03/25/2025 |
24:08.44.04 - Angiotensin-Converting Enzyme Inhibitors | class removed | 10/29/2024 |
24:08.44.08 - Angiotensin II Receptor Antagonists | class removed | 10/29/2024 |
24:08.44.20 - Mineralocorticoid (Aldosterone) Receptor Antagonists | class removed | 10/29/2024 |
34:04 - Nutritional supplement | New subclass | 08/28/2024 |
36:92 - Diagnostic Agents, Miscellaneous | class removed | 08/28/2024 |
48:34 - Dual Phosphodiesterase Inhibitors | New subclass | 06/28/2024 |
28:10 - Opoid Antagonists | Class name change from Opiate Antagonists to Opoid Antagonists | 05/28/2024 |
52:08.92 - Anti-inflammatory Agents, Miscellaneous | class removed | 05/28/2024 |
92:04 - Alcohol Deterrents | class removed | 05/28/2024 |
92:04 - 5-alpha-Reductase Inhibitors | Class number change from 92:08 to 92:04 | 05/28/2024 |
92:12 - Antidotes | class removed | 05/28/2024 |
92:36 - Disease-modifying Antirheumatic Drugs | class removed | 05/28/2024 |
92:44 - Immunosuppressive Agents | class removed | 05/28/2024 |
28:24.12 - Non-benzodiazepine Anxiolytics | New subclass | 05/24/2024 |
28:24.44 - Non-benzodiazepine Hypnotics | New subclass | 05/24/2024 |
28:24.48 - Melatonin Receptor Agonists | New subclass | 05/24/2024 |
28:36.24 - Adenosine A2A Receptor Antagonists | New subclass | 05/24/2024 |
28:44 - Amyotrophic Lateral Sclerosis (ALS) Agents | New subclass | 05/24/2024 |
52:44 - Macular Degeneration Agents | New subclass | 05/24/2024 |
91:32 - Benzodiazepine Antidotes | New subclass | 05/24/2024 |
91:32.04 - GABA-mediated Benzodiazepine Antidotes | New subclass | 05/24/2024 |
28:08.04.92 - Nonsteroidal Anti-inflammatory Agents, Miscellaneous | Class name change from Other Nonsteroidal Anti-inflammatory Agents to Nonsteroidal Anti-inflammatory Agents, Miscellaneous | 05/24/2024 |
28:08.08 - Opoid Agonists | name changed from Opiate to Opioid | 05/24/2024 |
28:08.12 - Opoid Partial Agonists | name changed from Opiate to Opioid | 05/24/2024 |
8:12.12.08 - Other Macrolides | class number changed from 8:12.12.92 to 8:12.12.08 | 05/21/2024 |
28:04.08 - Non-barbiturates | New subclass | 05/21/2024 |
28:08.04.04 - Reversible COX-1/COX-2 Inhibitors | New subclass | 05/21/2024 |
28:08.16 - Non-Opioid Analgesics | New subclass | 05/21/2024 |
28:12.24 - Ion Channel Inhibition Agents | New subclass | 05/21/2024 |
28:12.28 - GABA-mediated Anticonvulsants | New subclass | 05/21/2024 |
28:16.04.04 - GABA Modulators | New subclass | 05/21/2024 |
28:16.04.06 - NMDA Antagonists | New subclass | 05/21/2024 |
28:16.08.26 - Dibenzoxapines | New subclass | 05/21/2024 |
28:16.08.28 - Dihydroindolones | New subclass | 05/21/2024 |
28:16.08.30 - Diphenylbutylperidines | New subclass | 05/21/2024 |
91:02 - Alcohol Deterrents | New subclass | 04/27/2024 |
91:04 - Antidotes | New subclass | 04/27/2024 |
91:04.04 - Acetaminophen antidote | New subclass | 04/27/2024 |
91:04.08 - Methanol or ethylene glycol poisoning | New subclass | 04/27/2024 |
91:04.12 - Chemotherapy antidotes/protectants | New subclass | 04/27/2024 |
91:04.16 - Methemoglobinemia antidote | New subclass | 04/27/2024 |
91:04.20 - Organophosphate antidote | New subclass | 04/27/2024 |
91:04.24 - Cyanide antidotes | New subclass | 04/27/2024 |
91:04.28 - Neuromuscular blocking agent antidote | New subclass | 04/27/2024 |
91:04.32 - Fluoropyrimidine antidote | New subclass | 04/27/2024 |
52:04.24 - Astringents | New subclass | 04/26/2024 |
84:06.12 - Phosphodiesterase-4 Inhibitors | New subclass | 04/26/2024 |
84:06.16 - Janus Kinase Inhibitors | New subclass | 04/26/2024 |
84:06.24 - Adrenergic Agonists | New subclass | 04/26/2024 |
90:00 - Immunomodulatory Agents | New main class | 04/26/2024 |
90:04 - Multiple Sclerosis Agents | New subclass | 04/26/2024 |
90:04.04 - Monoclonal Antibodies | New subclass | 04/26/2024 |
90:04.08 - Fumarates | New subclass | 04/26/2024 |
90:04.12 - Interferons | New subclass | 04/26/2024 |
90:04.16 - Sphingosine 1-Phosphate (S1P) Agents | New subclass | 04/26/2024 |
90:04.20 - Antimetabolites | New subclass | 04/26/2024 |
90:04.24 - Amino Acid Polymers | New subclass | 04/26/2024 |
90:08 - Myasthenia Gravis Agents | New subclass | 04/26/2024 |
90:08.04 - Neonatal Fc Receptor Blockers | New subclass | 04/26/2024 |
90:08.08 - Complement Inhibitors | New subclass | 04/26/2024 |
90:10 - Alzheimer Disease Agents | New subclass | 04/26/2024 |
90:10.04 - Monoclonal Antibodies | New subclass | 04/26/2024 |
90:12 - Neuromyelitis Optica Spectrum Disorder Agents | New subclass | 04/26/2024 |
90:12.04 - Monoclonal Antibodies | New subclass | 04/26/2024 |
90:16 - Bone-modifying Agents | New subclass | 04/26/2024 |
90:20 - Complement Inhibitor Agents | New subclass | 04/26/2024 |
90:24 - Disease-modifying Antirheumatic Drugs | New subclass | 04/26/2024 |
90:24.04 - Monocarboxylic Acid Amide Agents | New subclass | 04/26/2024 |
90:24.08 - T-cell Blockers | New subclass | 04/26/2024 |
90:24.12 - Janus Kinase Inhibitors | New subclass | 04/26/2024 |
90:24.12.92 - Janus Kinase Inhibitors, Miscellaneous | New subclass | 04/26/2024 |
90:24.16 - Tumor Necrosis Factor Inhibitors | New subclass | 04/26/2024 |
90:24.16.92 - Tumor Necrosis Factor Inhibitors, Miscellaneous | New subclass | 04/26/2024 |
90:24.20 - Interleukin-mediated Agents | New subclass | 04/26/2024 |
90:24.20.92 - Interleukin-mediated Agents, Miscellaneous | New subclass | 04/26/2024 |
90:24.24 - Phosphodiesterase-4 Inhibitors | New subclass | 04/26/2024 |
90:24.24.92 - Phosphodiesterase-4 Inhibitors, Miscellaneous | New subclass | 04/26/2024 |
90:24.28 - IgG1 Monoclonal Antibodies | New subclass | 04/26/2024 |
90:24.92 - Disease-modifying Antirheumatic Drugs, Miscellaneous | New subclass | 04/26/2024 |
90:28 - Immunosuppressive Therapy | New subclass | 04/26/2024 |
90:28.04 - Polyclonal Antibodies | New subclass | 04/26/2024 |
90:28.04.92 - Polyclonal Antibodies, Miscellaneous | New subclass | 04/26/2024 |
90:28.08 - Antimetabolites, Immunosuppressive Therapy | New subclass | 04/26/2024 |
90:28.08.92 - Antimetabolites, Immunosuppressive Therapy, Miscellaneous | New subclass | 04/26/2024 |
90:28.12 - T-cell Costimulatory Blockers | New subclass | 04/26/2024 |
90:28.12.92 - T-cell Costimulatory Blockers, Miscellaneous | New subclass | 04/26/2024 |
90:28.16 - Interleukin Inhibitor Agents | New subclass | 04/26/2024 |
90:28.16.92 - Interleukin Inhibitor Agents, Miscellaneous | New subclass | 04/26/2024 |
90:28.20 - Interferon Gamma Inhibitor Agents | New subclass | 04/26/2024 |
90:28.20.92 - Interferon Gamma Inhibitor Agents, Miscellaneous | New subclass | 04/26/2024 |
90:28.24 - mTOR Inhibitors | New subclass | 04/26/2024 |
90:28.24.92 - mTOR Inhibitors, Miscellaneous | New subclass | 04/26/2024 |
90:28.28 - Calcineurin Inhibitors | New subclass | 04/26/2024 |
90:28.28.92 - Calcineurin Inhibitors, Miscellaneous | New subclass | 04/26/2024 |
91:00 - Antidote Therapeutics | New subclass | 04/26/2024 |
24:52 - Endothelin Receptor Antagonists | New subclass | 04/25/2024 |
34:00 - Dental Agents | New subclass | 04/25/2024 |
48:10.08.04 - Nasal Preparations | class removed | 04/25/2024 |
48:10.08.08 - Orally Inhaled Preparations | class removed | 04/25/2024 |
56:18 - Constipation Therapy | New main class | 04/25/2024 |
56:18.04 - Opioid Antagonists | New subclass | 04/25/2024 |
56:18.08 - Chloride Channel Activators | New subclass | 04/25/2024 |
56:18.12 - Guanylate Cyclase C (GCC) Receptor Agonists | New subclass | 04/25/2024 |
56:22.12 - Dopamine Receptor Antagonists | New subclass | 04/25/2024 |
56:22.24 - Cannabinoids | New subclass | 04/25/2024 |
84:18 - Antiproliferants | New subclass | 04/24/2024 |
08:14.20.00 - Triterpenoids | New subclass | 03/28/2024 |
8:16.08 - Antileprosy Agents | New subclass | 03/28/2024 |
8:18.30 - Endonuclease Inhibitors | New subclass | 03/28/2024 |
8:18.44 - CMV Antivirals | New subclass | 03/28/2024 |
8:18.48 - Coronavirus (COVID-19) | New subclass | 03/28/2024 |
8:30.12 - Antiprotozoals, Pneumocystis jirovecii Pneumonia | New subclass | 03/28/2024 |
8:30.16 - Antiprotozoals, Nitroimidazole-derivative | New subclass | 03/28/2024 |
8:30.16.04 - Nitroimidazole Derivatives, Trypanocidal | New subclass | 03/28/2024 |
8:30.16.08 - Nitroimidazole Derivatives, Anti-leishmanial | New subclass | 03/28/2024 |
8:30.16.92 - Nitroimidazole Derivatives, Miscellaneous | New subclass | 03/28/2024 |
8:30.20 - Antiprotozoals, Cryptosporidiosis | New subclass | 03/28/2024 |
20:04.08 - Liver and Stomach Preparations | Class removed | 03/28/2024 |
20:12.04.15 - Indirect Factor Xa Inhibitors | New subclass | 03/28/2024 |
20:12.04.20 - Antithrombin Replacements | New subclass | 03/28/2024 |
20:12.10 - von Willebrand Factor-related Antithrombotics | New subclass | 03/28/2024 |
24:06.07 - ACL Inhibitors | New subclass | 03/28/2024 |
24:06.20 - ANGPTL3 Inhibitors | New subclass | 03/28/2024 |
24:06.22 - Microsomal Triglyceride Transfer Protein (MTP) Inhibitors | New subclass | 03/28/2024 |
24:08 - Vasodilating Agents | class number changed from 24:12 to 24:08 | 03/28/2024 |
24:08.04 - alpha-Adrenergic Blocking Agents | class removed | 03/28/2024 |
24:08.08 - Nitrates and Nitrites | class number changed from 24:12.08 to 24:08.08 | 03/28/2024 |
24:08.10 - cGMP Synthesis Agent | New subclass | 03/28/2024 |
24:08.12 - Phosphodiesterase Type 5 Inhibitors | class number changed from 24:12.12 to 24:08.12 | 03/28/2024 |
24:08.12.08 - Dihydropyridines | class removed | 03/28/2024 |
24:08.12.92 - Calcium-Channel Blocking Agents, Miscellaneous | class removed | 03/28/2024 |
24:08.16 - Direct Vasodilators | class number changed from 24:08.20 to 24:08.16 | 03/28/2024 |
24:08.92 - Vasodilating Agents, Miscellaneous | title changed from "Hypotensive Agents, Miscellaneous" to "Vasodilating Agents, Miscellaneous" | 03/28/2024 |
24:12 - Sclerosing Agents | class number changed from 24:16 to 24:12 | 03/28/2024 |
24:16 - alpha-Adrenergic Blocking Agents | class number changed from 24:20 to 24:16 | 03/28/2024 |
24:20 - beta-Adrenergic Blocking Agents | class number changed from 24:24 to 24:20 | 03/28/2024 |
24:24 - Central alpha-Agonists | class number changed from 24:08.16 to 24:24 | 03/28/2024 |
24:32.12 - Angiotensin II Receptor Antagonists/Neprolysin Inhibitors | New subclass | 03/28/2024 |
24:36 - Diuretics | class number changed from 24:08.24 to 24:36 | 03/28/2024 |
24:36.04 - Carbonic Anhydrase Inhibitors | class number changed from 24:08.24.04 to 24:36.04 | 03/28/2024 |
24:36.08 - Loop Diuretics | class number changed from 24:08.24.08 to 24:36.08 | 03/28/2024 |
24:36.12 - Osmotic Diuretics | class number changed from 24:08.24.12 to 24:36.12 | 03/28/2024 |
24:36.16 - Potassium-sparing Diuretics | class number changed from 24:08.24.16 to 24:36.16 | 03/28/2024 |
24:36.20 - Thiazide Diuretics | class number changed from 24:08.24.20 to 24:36.20 | 03/28/2024 |
24:36.24 - Thiazide-like Diuretics | class number changed from 24:08.24.24 to 24:36.24 | 03/28/2024 |
24:36.92 - Diuretics, Miscellaneous | class number changed from 24:08.24.92 to 24:36.92 | 03/28/2024 |
24:44 - Cardiovascular Drugs, Nonsteroidal Anti-inflammatory | New subclass | 03/28/2024 |
24:48 - Kallikrein-Kinin System Inhibitors | class number changed from 92:32 to 24:48 | 03/28/2024 |
24:48.04 - Bradykinin Receptor Antagonists | class number changed from 92:32.04 to 24:48.04 | 03/28/2024 |
24:48.08 - Kallikrein Inhibitors | class number changed from 92:32.12 to 24:48.08 | 03/28/2024 |
44:04 - Enzyme Inhibitors | New subclass | 03/28/2024 |
44:08 - Enzyme Cofactors/Chaperones | New subclass | 03/28/2024 |
56:44 - Immunomodulatory Agents | New subclass | 10/17/2023 |
24:32.20.04 - Nonsteroidal Mineralocorticoid Receptor Antagonists | New subclass | 10/04/2023 |
24:32.20.08 - Steroidal Mineralocorticoid Receptor Antagonists | New subclass | 10/04/2023 |
12:20.20.24 - Botulinum toxins | New subclass | 09/18/2023 |
68:48 Melanocortin receptor agonists | New subclass | 06/13/2023 |
24:40 Sodium-glucose (SGLT) Cotransporter Inhibitors | New subclass | 05/30/2023 |
48:48.12 - Endothelin receptor agonists | New subclass | 02/14/2023 |
48:48.24 - Phosphodiesterase type 5 inhibitors | New subclass | 02/14/2023 |
48:48.28 - Prostacyclin and prostacyclin derivatives | New subclass | 02/14/2023 |
48:48.92 - Vasodilating agents, miscellaneous | New subclass | 02/14/2023 |
56:28.18 Potassium-competitive acid blockers | New subclass | 05/05/2022 |
52:56 - Vascular Endothelial Growth Factor Antagonists | New subclass | 02/01/2022 |
28:24.40 - Orexin Receptor Antagonists | New subclass | 01/12/2022 |
92:32 - Kallikrein-Kinin System Inhibitors | Rename class from Complement Inhibitors | 01/12/2022 |
92:32.04 - Bradykinin receptor antagonists | New subclass | 01/12/2022 |
92:32.08 - Complement Inhibitors | New subclass | 01/12/2022 |
92:32.12 - Kallikrein Inhibitors | New subclass | 01/12/2022 |
32:00 - Nonhormonal Contraceptives | Rename class from Contraceptives (foams, devices) | 06/01/2020 |
8:12.06.28 - Siderophore Cephalosporins | New subclass | 11/14/2019 |
8:12.28.26 - Pleuromutilins | New subclass | 08/19/2019 |
92:22 - Bone Anabolic Agents | New subclass | 04/10/2019 |
28:32.12 - Calcitonin Gene-related Peptide (CGRP) Antagonists | New subclass | 02/25/2019 |
52:40.32 - Rho Kinase Inhibitors | New subclass | 11/01/2018 |
8:12.24.04 - Aminomethylcyclines | New subclass | 10/01/2018 |
68:20.08.04 - Rapid-Acting Insulins | New subclass | 09/25/2018 |
68:20.08.08 - Short-Acting Insulins | New subclass | 09/25/2018 |
68:20.08.12 - Intermediate-Acting Insulins | New subclass | 09/25/2018 |
68:20.08.16 - Long-Acting Insulins | New subclass | 09/25/2018 |
8:12.24.08 - Fluorocyclines | New subclass | 08/27/2018 |
40:92 - Electrolytic, Caloric, and Water Balance Agents; Misc | New subclass | 04/01/2018 |
68:44 - Renin-Angiotensin-Aldosterone System (RAAS) | New subclass | 12/21/2017 |
84:06.08 - Corticosteroids | New subclass | 12/15/2017 |
84:06.20 - Nonsteroidal Anti-inflammatory Agents | New subclass | 12/15/2017 |
84:06.92 - Anti-inflammatory Agents, Miscellaneous | New subclass | 12/15/2017 |
28:56 - Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors | New subclass | 10/16/2017 |
68:16.08 - Antiestrogens | Revived old class that was retired in 2007 | 09/20/2017 |
92:18 - Antisense Oligonucleotides | New subclass | 09/20/2017 |
68:18 - Gonadotropins and Antigonadotropins | Rename class from Gonadotropins | 09/15/2017 |
68:18.04 - Antigonadotropins | New subclass | 09/15/2017 |
68:18.08 - Gonadotropins | New subclass | 09/15/2017 |
26:00 - Cellular and Gene Therapy | Rename class from Cellular Therapy | 09/08/2017 |
26:04 - Cellular Therapy | New subclass | 09/08/2017 |
26:12 - Gene Therapy | New subclass | 09/08/2017 |
68:24 - Parathyroid and Antiparathyroid Agents | Rename class from Parathyroid | 08/10/2017 |
68:24.04 - Antiparathyroid Agents | New subclass | 08/10/2017 |
68:24.08 - Parathyroid Agents | New subclass | 08/10/2017 |
80:00 - Antitoxins, Immune Globulins, Toxoids, and Vaccines | Rename class from Serums, Toxoids, and Vaccines | 09/14/2016 |
80:02 - Allergenic Extracts | New subclass; products for therapeutic indications go here, products for diagnostic indications go under 36:06 | 09/14/2016 |
80:04 - Antitoxins and Immune Globulins | Rename class from Serums | 09/14/2016 |
56:22.32 - Neurokinin-1 Receptor Antagonists | New subclass | 06/09/2016 |
92:26 - Carbonic Anhydrase Inhibitors | New subclass | 05/13/2016 |
48:10.20 - Interleukin Antagonists | New subclass | 04/20/2016 |
20:12.92 - Antithrombotic Agents, Misc | New subclass | 03/31/2016 |
24:06.24 - Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Inhibitors | New subclass | 11/04/2015 |
20:28.92 - Antihemorrhagic Agents, Misc | New subclass | 10/20/2015 |
48:02 - Antifibrotic Agents | New subclass | 09/29/2015 |
36:46 - Lymphatic System | New subclass | 01/29/2015 |
36:06 - Allergenic Extracts | New classification; products for diagnostic purposes go under this class; products for therapeutic purposes go under 80:02 | 11/11/2014 |
28:20.08.92 - Anorexigenic Agents, Miscellaneous | New classification | 09/10/2014 |
84:04.08.24 - Oxaboroles | New classification | 07/09/2014 |
8:18.08.12 - HIV Integrase Inhibitors | Name change; added "HIV" | 04/25/2014 |
8:18.08.16 - HIV Nonnucleoside Reverse Transcriptase Inhibitors | Name change; added "HIV" | 04/25/2014 |
8:18.08.20 - HIV Nucleoside and Nucleotide Reverse Transcriptase Inhibitors | Name change; added "HIV" | 04/25/2014 |
8:18.40 - HCV Antivirals | Name change from "HCV Protease Inhibitors" to "HCV Antivirals" | 04/25/2014 |
8:18.40.16 - HCV Polymerase Inhibitors | New classification | 04/25/2014 |
8:18.40.20 - HCV Protease Inhibitors | New classification | 04/25/2014 |
68:40 - Leptins | New classification | 03/05/2014 |
68:29 - Somatostatin Agonists and Antagonists | New classification | 09/01/2013 |
68:29.04 - Somatostatin Agonists | New classification | 09/01/2013 |
68:29.08 - Somatostatin Antagonists | New classification | 09/01/2013 |
92:20 - Immunomodulatory Agents | Name change | 09/01/2013 |
86:12.04 - Antimuscarinics | New classification | 07/01/2013 |
86:12.08 - β3-Adrenergic Agonists | New classification | 07/01/2013 |
86:12.08.12 - Selective β3-Adrenergic Agonists | New classification | 07/01/2013 |
68:20.18 - Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors | New classification | 04/03/2013 |
28:20 - Anorexigenic Agents and Respiratory and CNS Stimulants | Name Change | 01/01/2013 |
28:20.08 - Anorexigenic Agents | New classification | 01/01/2013 |
28:20.08.04 - Amphetamine Derivatives | New classification | 01/01/2013 |
28:20.08.32 - Selective Serotonin Receptor Agonists | New classification | 01/01/2013 |
28:20.32 - Respiratory and CNS Stimulants | New classification | 01/01/2013 |
28:20.80 - Wakefulness-promoting Agents | New classification | 01/01/2013 |
28:20.92 - Anorexigenic Agents and Stimulants, Miscellaneous | Name Change | 01/01/2013 |
48:14 - Cystic Fibrosis Transmembrane Conductance Regulator Modulators | New classification | 01/01/2013 |
48:14.04 - Cystic Fibrosis Transmembrane Conductance Regulator Correctors | New classification | 01/01/2013 |
48:14.12 - Cystic Fibrosis Transmembrane Conductance Regulator Potentiators | New classification | 01/01/2013 |