AHFS Class Changes

The following describes drug assignments and changes to the AHFS Pharmacologic-Therapeutic Classification©. This is only a partial listing of the AHFS classification system. The full classification, along with a list of drugs covered in AHFS DI and their corresponding classes, is available in the print edition of AHFS and electronically as a dataset that can be licensed. Reproduction, storage on a retrieval system, or transmission of this material or any part thereof in any form or by any means without the express written permission of the American Society of Health-System Pharmacists is prohibited.

Please contact us at ahfs@ashp.org if you have any questions.

AHFS Class Changes

AHFS Class Change Description Change Date
8:12.28.36 - Triazaacenaphthylenes New subclass 03/25/2025
24:08.44.04 - Angiotensin-Converting Enzyme Inhibitors class removed 10/29/2024
24:08.44.08 - Angiotensin II Receptor Antagonists class removed 10/29/2024
24:08.44.20 - Mineralocorticoid (Aldosterone) Receptor Antagonists class removed 10/29/2024
34:04 - Nutritional supplement New subclass 08/28/2024
36:92 - Diagnostic Agents, Miscellaneous class removed 08/28/2024
48:34 - Dual Phosphodiesterase Inhibitors New subclass 06/28/2024
28:10 - Opoid Antagonists Class name change from Opiate Antagonists to Opoid Antagonists 05/28/2024
52:08.92 - Anti-inflammatory Agents, Miscellaneous class removed 05/28/2024
92:04 - Alcohol Deterrents class removed 05/28/2024
92:04 - 5-alpha-Reductase Inhibitors Class number change from 92:08 to 92:04 05/28/2024
92:12 - Antidotes class removed 05/28/2024
92:36 - Disease-modifying Antirheumatic Drugs class removed 05/28/2024
92:44 - Immunosuppressive Agents class removed 05/28/2024
28:24.12 - Non-benzodiazepine Anxiolytics New subclass 05/24/2024
28:24.44 - Non-benzodiazepine Hypnotics New subclass 05/24/2024
28:24.48 - Melatonin Receptor Agonists New subclass 05/24/2024
28:36.24 - Adenosine A2A Receptor Antagonists New subclass 05/24/2024
28:44 - Amyotrophic Lateral Sclerosis (ALS) Agents New subclass 05/24/2024
52:44 - Macular Degeneration Agents New subclass 05/24/2024
91:32 - Benzodiazepine Antidotes New subclass 05/24/2024
91:32.04 - GABA-mediated Benzodiazepine Antidotes New subclass 05/24/2024
28:08.04.92 - Nonsteroidal Anti-inflammatory Agents, Miscellaneous Class name change from Other Nonsteroidal Anti-inflammatory Agents to Nonsteroidal Anti-inflammatory Agents, Miscellaneous 05/24/2024
28:08.08 - Opoid Agonists name changed from Opiate to Opioid 05/24/2024
28:08.12 - Opoid Partial Agonists name changed from Opiate to Opioid 05/24/2024
8:12.12.08 - Other Macrolides class number changed from 8:12.12.92 to 8:12.12.08 05/21/2024
28:04.08 - Non-barbiturates New subclass 05/21/2024
28:08.04.04 - Reversible COX-1/COX-2 Inhibitors New subclass 05/21/2024
28:08.16 - Non-Opioid Analgesics New subclass 05/21/2024
28:12.24 - Ion Channel Inhibition Agents New subclass 05/21/2024
28:12.28 - GABA-mediated Anticonvulsants New subclass 05/21/2024
28:16.04.04 - GABA Modulators New subclass 05/21/2024
28:16.04.06 - NMDA Antagonists New subclass 05/21/2024
28:16.08.26 - Dibenzoxapines New subclass 05/21/2024
28:16.08.28 - Dihydroindolones New subclass 05/21/2024
28:16.08.30 - Diphenylbutylperidines New subclass 05/21/2024
91:02 - Alcohol Deterrents New subclass 04/27/2024
91:04 - Antidotes New subclass 04/27/2024
91:04.04 - Acetaminophen antidote New subclass 04/27/2024
91:04.08 - Methanol or ethylene glycol poisoning New subclass 04/27/2024
91:04.12 - Chemotherapy antidotes/protectants New subclass 04/27/2024
91:04.16 - Methemoglobinemia antidote New subclass 04/27/2024
91:04.20 - Organophosphate antidote New subclass 04/27/2024
91:04.24 - Cyanide antidotes New subclass 04/27/2024
91:04.28 - Neuromuscular blocking agent antidote New subclass 04/27/2024
91:04.32 - Fluoropyrimidine antidote New subclass 04/27/2024
52:04.24 - Astringents New subclass 04/26/2024
84:06.12 - Phosphodiesterase-4 Inhibitors New subclass 04/26/2024
84:06.16 - Janus Kinase Inhibitors New subclass 04/26/2024
84:06.24 - Adrenergic Agonists New subclass 04/26/2024
90:00 - Immunomodulatory Agents New main class 04/26/2024
90:04 - Multiple Sclerosis Agents New subclass 04/26/2024
90:04.04 - Monoclonal Antibodies New subclass 04/26/2024
90:04.08 - Fumarates New subclass 04/26/2024
90:04.12 - Interferons New subclass 04/26/2024
90:04.16 - Sphingosine 1-Phosphate (S1P) Agents New subclass 04/26/2024
90:04.20 - Antimetabolites New subclass 04/26/2024
90:04.24 - Amino Acid Polymers New subclass 04/26/2024
90:08 - Myasthenia Gravis Agents New subclass 04/26/2024
90:08.04 - Neonatal Fc Receptor Blockers New subclass 04/26/2024
90:08.08 - Complement Inhibitors New subclass 04/26/2024
90:10 - Alzheimer Disease Agents New subclass 04/26/2024
90:10.04 - Monoclonal Antibodies New subclass 04/26/2024
90:12 - Neuromyelitis Optica Spectrum Disorder Agents New subclass 04/26/2024
90:12.04 - Monoclonal Antibodies New subclass 04/26/2024
90:16 - Bone-modifying Agents New subclass 04/26/2024
90:20 - Complement Inhibitor Agents New subclass 04/26/2024
90:24 - Disease-modifying Antirheumatic Drugs New subclass 04/26/2024
90:24.04 - Monocarboxylic Acid Amide Agents New subclass 04/26/2024
90:24.08 - T-cell Blockers New subclass 04/26/2024
90:24.12 - Janus Kinase Inhibitors New subclass 04/26/2024
90:24.12.92 - Janus Kinase Inhibitors, Miscellaneous New subclass 04/26/2024
90:24.16 - Tumor Necrosis Factor Inhibitors New subclass 04/26/2024
90:24.16.92 - Tumor Necrosis Factor Inhibitors, Miscellaneous New subclass 04/26/2024
90:24.20 - Interleukin-mediated Agents New subclass 04/26/2024
90:24.20.92 - Interleukin-mediated Agents, Miscellaneous New subclass 04/26/2024
90:24.24 - Phosphodiesterase-4 Inhibitors New subclass 04/26/2024
90:24.24.92 - Phosphodiesterase-4 Inhibitors, Miscellaneous New subclass 04/26/2024
90:24.28 - IgG1 Monoclonal Antibodies New subclass 04/26/2024
90:24.92 - Disease-modifying Antirheumatic Drugs, Miscellaneous New subclass 04/26/2024
90:28 - Immunosuppressive Therapy New subclass 04/26/2024
90:28.04 - Polyclonal Antibodies New subclass 04/26/2024
90:28.04.92 - Polyclonal Antibodies, Miscellaneous New subclass 04/26/2024
90:28.08 - Antimetabolites, Immunosuppressive Therapy New subclass 04/26/2024
90:28.08.92 - Antimetabolites, Immunosuppressive Therapy, Miscellaneous New subclass 04/26/2024
90:28.12 - T-cell Costimulatory Blockers New subclass 04/26/2024
90:28.12.92 - T-cell Costimulatory Blockers, Miscellaneous New subclass 04/26/2024
90:28.16 - Interleukin Inhibitor Agents New subclass 04/26/2024
90:28.16.92 - Interleukin Inhibitor Agents, Miscellaneous New subclass 04/26/2024
90:28.20 - Interferon Gamma Inhibitor Agents New subclass 04/26/2024
90:28.20.92 - Interferon Gamma Inhibitor Agents, Miscellaneous New subclass 04/26/2024
90:28.24 - mTOR Inhibitors New subclass 04/26/2024
90:28.24.92 - mTOR Inhibitors, Miscellaneous New subclass 04/26/2024
90:28.28 - Calcineurin Inhibitors New subclass 04/26/2024
90:28.28.92 - Calcineurin Inhibitors, Miscellaneous New subclass 04/26/2024
91:00 - Antidote Therapeutics New subclass 04/26/2024
24:52 - Endothelin Receptor Antagonists New subclass 04/25/2024
34:00 - Dental Agents New subclass 04/25/2024
48:10.08.04 - Nasal Preparations class removed 04/25/2024
48:10.08.08 - Orally Inhaled Preparations class removed 04/25/2024
56:18 - Constipation Therapy New main class 04/25/2024
56:18.04 - Opioid Antagonists New subclass 04/25/2024
56:18.08 - Chloride Channel Activators New subclass 04/25/2024
56:18.12 - Guanylate Cyclase C (GCC) Receptor Agonists New subclass 04/25/2024
56:22.12 - Dopamine Receptor Antagonists New subclass 04/25/2024
56:22.24 - Cannabinoids New subclass 04/25/2024
84:18 - Antiproliferants New subclass 04/24/2024
08:14.20.00 - Triterpenoids New subclass 03/28/2024
8:16.08 - Antileprosy Agents New subclass 03/28/2024
8:18.30 - Endonuclease Inhibitors New subclass 03/28/2024
8:18.44 - CMV Antivirals New subclass 03/28/2024
8:18.48 - Coronavirus (COVID-19) New subclass 03/28/2024
8:30.12 - Antiprotozoals, Pneumocystis jirovecii Pneumonia New subclass 03/28/2024
8:30.16 - Antiprotozoals, Nitroimidazole-derivative New subclass 03/28/2024
8:30.16.04 - Nitroimidazole Derivatives, Trypanocidal New subclass 03/28/2024
8:30.16.08 - Nitroimidazole Derivatives, Anti-leishmanial New subclass 03/28/2024
8:30.16.92 - Nitroimidazole Derivatives, Miscellaneous New subclass 03/28/2024
8:30.20 - Antiprotozoals, Cryptosporidiosis New subclass 03/28/2024
20:04.08 - Liver and Stomach Preparations Class removed 03/28/2024
20:12.04.15 - Indirect Factor Xa Inhibitors New subclass 03/28/2024
20:12.04.20 - Antithrombin Replacements New subclass 03/28/2024
20:12.10 - von Willebrand Factor-related Antithrombotics New subclass 03/28/2024
24:06.07 - ACL Inhibitors New subclass 03/28/2024
24:06.20 - ANGPTL3 Inhibitors New subclass 03/28/2024
24:06.22 - Microsomal Triglyceride Transfer Protein (MTP) Inhibitors New subclass 03/28/2024
24:08 - Vasodilating Agents class number changed from 24:12 to 24:08 03/28/2024
24:08.04 - alpha-Adrenergic Blocking Agents class removed 03/28/2024
24:08.08 - Nitrates and Nitrites class number changed from 24:12.08 to 24:08.08 03/28/2024
24:08.10 - cGMP Synthesis Agent New subclass 03/28/2024
24:08.12 - Phosphodiesterase Type 5 Inhibitors class number changed from 24:12.12 to 24:08.12 03/28/2024
24:08.12.08 - Dihydropyridines class removed 03/28/2024
24:08.12.92 - Calcium-Channel Blocking Agents, Miscellaneous class removed 03/28/2024
24:08.16 - Direct Vasodilators class number changed from 24:08.20 to 24:08.16 03/28/2024
24:08.92 - Vasodilating Agents, Miscellaneous title changed from "Hypotensive Agents, Miscellaneous" to "Vasodilating Agents, Miscellaneous" 03/28/2024
24:12 - Sclerosing Agents class number changed from 24:16 to 24:12 03/28/2024
24:16 - alpha-Adrenergic Blocking Agents class number changed from 24:20 to 24:16 03/28/2024
24:20 - beta-Adrenergic Blocking Agents class number changed from 24:24 to 24:20 03/28/2024
24:24 - Central alpha-Agonists class number changed from 24:08.16 to 24:24 03/28/2024
24:32.12 - Angiotensin II Receptor Antagonists/Neprolysin Inhibitors New subclass 03/28/2024
24:36 - Diuretics class number changed from 24:08.24 to 24:36 03/28/2024
24:36.04 - Carbonic Anhydrase Inhibitors class number changed from 24:08.24.04 to 24:36.04 03/28/2024
24:36.08 - Loop Diuretics class number changed from 24:08.24.08 to 24:36.08 03/28/2024
24:36.12 - Osmotic Diuretics class number changed from 24:08.24.12 to 24:36.12 03/28/2024
24:36.16 - Potassium-sparing Diuretics class number changed from 24:08.24.16 to 24:36.16 03/28/2024
24:36.20 - Thiazide Diuretics class number changed from 24:08.24.20 to 24:36.20 03/28/2024
24:36.24 - Thiazide-like Diuretics class number changed from 24:08.24.24 to 24:36.24 03/28/2024
24:36.92 - Diuretics, Miscellaneous class number changed from 24:08.24.92 to 24:36.92 03/28/2024
24:44 - Cardiovascular Drugs, Nonsteroidal Anti-inflammatory New subclass 03/28/2024
24:48 - Kallikrein-Kinin System Inhibitors class number changed from 92:32 to 24:48 03/28/2024
24:48.04 - Bradykinin Receptor Antagonists class number changed from 92:32.04 to 24:48.04 03/28/2024
24:48.08 - Kallikrein Inhibitors class number changed from 92:32.12 to 24:48.08 03/28/2024
44:04 - Enzyme Inhibitors New subclass 03/28/2024
44:08 - Enzyme Cofactors/Chaperones New subclass 03/28/2024
56:44 - Immunomodulatory Agents New subclass 10/17/2023
24:32.20.04 - Nonsteroidal Mineralocorticoid Receptor Antagonists New subclass 10/04/2023
24:32.20.08 - Steroidal Mineralocorticoid Receptor Antagonists New subclass 10/04/2023
12:20.20.24 - Botulinum toxins New subclass 09/18/2023
68:48 Melanocortin receptor agonists New subclass 06/13/2023
24:40 Sodium-glucose (SGLT) Cotransporter Inhibitors New subclass 05/30/2023
48:48.12 - Endothelin receptor agonists New subclass 02/14/2023
48:48.24 - Phosphodiesterase type 5 inhibitors New subclass 02/14/2023
48:48.28 - Prostacyclin and prostacyclin derivatives New subclass 02/14/2023
48:48.92 - Vasodilating agents, miscellaneous New subclass 02/14/2023
56:28.18 Potassium-competitive acid blockers New subclass 05/05/2022
52:56 - Vascular Endothelial Growth Factor Antagonists New subclass 02/01/2022
28:24.40 - Orexin Receptor Antagonists New subclass 01/12/2022
92:32 - Kallikrein-Kinin System Inhibitors Rename class from Complement Inhibitors 01/12/2022
92:32.04 - Bradykinin receptor antagonists New subclass 01/12/2022
92:32.08 - Complement Inhibitors New subclass 01/12/2022
92:32.12 - Kallikrein Inhibitors New subclass 01/12/2022
32:00 - Nonhormonal Contraceptives Rename class from Contraceptives (foams, devices) 06/01/2020
8:12.06.28 - Siderophore Cephalosporins New subclass 11/14/2019
8:12.28.26 - Pleuromutilins New subclass 08/19/2019
92:22 - Bone Anabolic Agents New subclass 04/10/2019
28:32.12 - Calcitonin Gene-related Peptide (CGRP) Antagonists New subclass 02/25/2019
52:40.32 - Rho Kinase Inhibitors New subclass 11/01/2018
8:12.24.04 - Aminomethylcyclines New subclass 10/01/2018
68:20.08.04 - Rapid-Acting Insulins New subclass 09/25/2018
68:20.08.08 - Short-Acting Insulins New subclass 09/25/2018
68:20.08.12 - Intermediate-Acting Insulins New subclass 09/25/2018
68:20.08.16 - Long-Acting Insulins New subclass 09/25/2018
8:12.24.08 - Fluorocyclines New subclass 08/27/2018
40:92 - Electrolytic, Caloric, and Water Balance Agents; Misc New subclass 04/01/2018
68:44 - Renin-Angiotensin-Aldosterone System (RAAS) New subclass 12/21/2017
84:06.08 - Corticosteroids New subclass 12/15/2017
84:06.20 - Nonsteroidal Anti-inflammatory Agents New subclass 12/15/2017
84:06.92 - Anti-inflammatory Agents, Miscellaneous New subclass 12/15/2017
28:56 - Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors New subclass 10/16/2017
68:16.08 - Antiestrogens Revived old class that was retired in 2007 09/20/2017
92:18 - Antisense Oligonucleotides New subclass 09/20/2017
68:18 - Gonadotropins and Antigonadotropins Rename class from Gonadotropins 09/15/2017
68:18.04 - Antigonadotropins New subclass 09/15/2017
68:18.08 - Gonadotropins New subclass 09/15/2017
26:00 - Cellular and Gene Therapy Rename class from Cellular Therapy 09/08/2017
26:04 - Cellular Therapy New subclass 09/08/2017
26:12 - Gene Therapy New subclass 09/08/2017
68:24 - Parathyroid and Antiparathyroid Agents Rename class from Parathyroid 08/10/2017
68:24.04 - Antiparathyroid Agents New subclass 08/10/2017
68:24.08 - Parathyroid Agents New subclass 08/10/2017
80:00 - Antitoxins, Immune Globulins, Toxoids, and Vaccines Rename class from Serums, Toxoids, and Vaccines 09/14/2016
80:02 - Allergenic Extracts New subclass; products for therapeutic indications go here, products for diagnostic indications go under 36:06 09/14/2016
80:04 - Antitoxins and Immune Globulins Rename class from Serums 09/14/2016
56:22.32 - Neurokinin-1 Receptor Antagonists New subclass 06/09/2016
92:26 - Carbonic Anhydrase Inhibitors New subclass 05/13/2016
48:10.20 - Interleukin Antagonists New subclass 04/20/2016
20:12.92 - Antithrombotic Agents, Misc New subclass 03/31/2016
24:06.24 - Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Inhibitors New subclass 11/04/2015
20:28.92 - Antihemorrhagic Agents, Misc New subclass 10/20/2015
48:02 - Antifibrotic Agents New subclass 09/29/2015
36:46 - Lymphatic System New subclass 01/29/2015
36:06 - Allergenic Extracts New classification; products for diagnostic purposes go under this class; products for therapeutic purposes go under 80:02 11/11/2014
28:20.08.92 - Anorexigenic Agents, Miscellaneous New classification 09/10/2014
84:04.08.24 - Oxaboroles New classification 07/09/2014
8:18.08.12 - HIV Integrase Inhibitors Name change; added "HIV" 04/25/2014
8:18.08.16 - HIV Nonnucleoside Reverse Transcriptase Inhibitors Name change; added "HIV" 04/25/2014
8:18.08.20 - HIV Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Name change; added "HIV" 04/25/2014
8:18.40 - HCV Antivirals Name change from "HCV Protease Inhibitors" to "HCV Antivirals" 04/25/2014
8:18.40.16 - HCV Polymerase Inhibitors New classification 04/25/2014
8:18.40.20 - HCV Protease Inhibitors New classification 04/25/2014
68:40 - Leptins New classification 03/05/2014
68:29 - Somatostatin Agonists and Antagonists New classification 09/01/2013
68:29.04 - Somatostatin Agonists New classification 09/01/2013
68:29.08 - Somatostatin Antagonists New classification 09/01/2013
92:20 - Immunomodulatory Agents Name change 09/01/2013
86:12.04 - Antimuscarinics New classification 07/01/2013
86:12.08 - β3-Adrenergic Agonists New classification 07/01/2013
86:12.08.12 - Selective β3-Adrenergic Agonists New classification 07/01/2013
68:20.18 - Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors New classification 04/03/2013
28:20 - Anorexigenic Agents and Respiratory and CNS Stimulants Name Change 01/01/2013
28:20.08 - Anorexigenic Agents New classification 01/01/2013
28:20.08.04 - Amphetamine Derivatives New classification 01/01/2013
28:20.08.32 - Selective Serotonin Receptor Agonists New classification 01/01/2013
28:20.32 - Respiratory and CNS Stimulants New classification 01/01/2013
28:20.80 - Wakefulness-promoting Agents New classification 01/01/2013
28:20.92 - Anorexigenic Agents and Stimulants, Miscellaneous Name Change 01/01/2013
48:14 - Cystic Fibrosis Transmembrane Conductance Regulator Modulators New classification 01/01/2013
48:14.04 - Cystic Fibrosis Transmembrane Conductance Regulator Correctors New classification 01/01/2013
48:14.12 - Cystic Fibrosis Transmembrane Conductance Regulator Potentiators New classification 01/01/2013